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KMID : 0378119870140010226
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Chungnam Medical Journal
1987 Volume.14 No. 1 p.226 ~ p.240
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An Ultrastructural Study on the Kidney of Rat with Calcium Oxalate Nephrocalcinkosis induced by 6% Glycolic Acid Containing Diet
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Abstract
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An ultrastructural study on kidney of rat with experimental calcium oxalate nephrocalcino?? was carried out to investigate changes of renal tissue and pathogenesis of nephocalcinosis. Sprague-Dawley rats were fed with diet containing 6% of glycolic acid for 2 and 4 weeks and than sacrificed. The kidneys were observed with light and electron microscope.
The calcium oxalate crystals were distributed predominantly in proximal tubules and also present occasionally in distal tubules, collecting tubules and interstitium. The tubular epithelial cells were markedly atrophic and denuded in areas of crystals impacted. Pronounced vacuolization of cytoplasms, loss of microvilli in luminal suface, and diminished cell organelles occured in tubular eplthelium without crystallization. Most crystals were present in intratubule but some of the crystals were seen in interstitial and fibroblastic tissue. There were numbers of degraded cell olganell?? membranous structures, and amorphous granular materials in matrices of the crystals.
On the basis of the above results, it is postulated that intratubular crystals might induce the injury of epithelial cells in calcium oxalate nephrocalcinosis and then cell debris and proteins released from the damaged epithelial cells might cause growth of or crystals and formation of renal stones.
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